One of the top runners in the league will be featured when James Cook and the Buffalo Bills visit the New England Patriots on Sunday, January 5, 2025.
The Patriots rank third-worst in points per game (16.6), but they’ve been more productive defensively, ranking 25th in the NFL with 25.1 points surrendered per contest. From an offensive standpoint, the Bills rank ninth in the NFL with 365.4 yards per game. Meanwhile, they rank 20th in total defense (343.6 yards allowed per contest).
Patriots vs Bills: live streaming info, TV channel & game time
Patriots vs Bills betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 10:53 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: Bills (-3.5)
- Moneyline: Bills (-190), Patriots (+158)
- Total: 35.5 points
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