🗓️ Week 1: Saints vs. Cardinals
Date: Sunday, Sept. 7, 2025
Time: Noon CT
Location: Caesars Superdome, New Orleans, LA
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Quick Take: The Cardinals lead the all-time regular season series 16-15…New Orleans won the last matchup in the Caesars Superdome 31-9, on Oct. 27, 2019…The Saints have an 8-4 regular season home record against the Cardinals, in addition to a 45-14 win in the 2009 NFC Wild Card Playoff…This is the third time the Saints will open up the season against the Cardinals, having lost the 1982 matchup at the Superdome and the 2015 opener in Glendale, Ariz…The Saints have won six consecutive season openers, the current longest such streak in the NFL…This will be the third straight campaign the Saints have opened their season in the Caesars Superdome…Saints S Tyrann Mathieu was originally a third-round pick of the Cardinals in the 2013 NFL Draft and spent his first five seasons in Arizona…Saints DE Cameron Jordan (Chandler HS) and QBs Spencer Rattler (Pinnacle HS in Phoenix) and Tyler Shough (Hamilton HS in Chandler) all grew up in the greater Phoenix area…Saints Edges Coach Jay Rodgers’ brother, Richard, serves as assistant head coach & special teams coordinator for the Cardinals.
🗓️ Week 2: Saints vs. 49ers
Date: Sunday, Sept. 14, 2025
Time: Noon CT
Location: Caesars Superdome, New Orleans, LA
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Quick Take: This matchup will mark the first time since 2018 that the Saints have opened at home for their first two games…Old NFC West rivals for 31 seasons (1970-2001)…San Francisco leads the all-time regular season series 49-27-2…New Orleans Defensive Coordinator Brandon Staley served as San Francisco’s assistant head coach/defense in 2024…Quarterbacks Coach Scott Tolzien served as a backup signal-caller in San Francisco for two seasons (2011-12)…CB Isaac Yiadom spent the 2024 season with the 49ers, where he appeared in all 17 contests with five starts, finishing with a career-high 44 tackles (career-best 36 solo), one interception, six pass breakups, a career-best two forced fumbles, one fumble recovery, two special teams stops and a recovery of a muffed punt.
🗓️ Week 3: Saints at Seahawks
Date: Sunday, Sept. 21, 2025
Time: 3:05 PM CT
Location: Lumen Field, Seattle, WA
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Quick Take: The Saints lead the all-time series matchup against Seattle 10-6, marking the club’s best winning percentage (.625) versus an NFL opponent that…
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