2022 Independence Bowl prediction, odds, line, spread: Houston vs. Louisiana picks, best bets by proven model

The American Athletic Conference meets the Sun Belt when the Houston Cougars and Louisiana Ragin’ Cajuns in the 2022 Independence Bowl on Friday at Independence Stadium in Shreveport, La. The Cougars (7-5) tied for second in the West division of The American. Friday’s game will be Houston’s last in the conference before beginning play next season in the Big 12. Meanwhile the Ragin’ Cajuns (6-6) tied for third in the West division of the Sun Belt in coach Michael Desormeaux’s first season at the helm in Lafayette. They are looking to win their fourth bowl game in four seasons. Louisiana has four players — defensive end Andre Jones, running back Chris Smith and receivers Dontae Fleming and Michael Jefferson — who have opted out of this matchup.

Kickoff is 3 p.m. ET. The Cougars are 7-point favorites in the latest Houston vs. Louisiana odds from Caesars Sportsbook, while the over/under for total points scored is 57. Before you make any Louisiana vs. Houston picks, you need to see the Independence Bowl predictions and betting advice what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now the model has dialed in on Houston vs. Louisiana and just revealed its coveted picks and Independence Bowl 2022 predictions. You can head to SportsLine now to see all of the model’s college football picks. Now, here are the college football odds and betting lines for Louisiana vs. Houston:  

• Houston vs. Louisiana spread: Cougars -7 
• Houston vs. Louisiana over/under: 57 points 
• Houston vs. Louisiana money line: Cougars -267, Ragin’ Cajuns +215
• HOU: QB Clayton Tune is tied for the nation’s lead in touchdown passes (37) 
• ULL: The Ragin’ Cajuns rank 11th in the country in interceptions (15) 
• Houston vs. Louisiana picks: See picks here