Michigan vs. Colorado State odds, prediction: 2022 Week 1 college football picks, bets by model on 45-32 run

Michigan Stadium hosts a season-opening tilt on Saturday afternoon in Ann Arbor when Jim Harbaugh and the No. 8 Michigan Wolverines take on first-year head coach Jay Norvell and the Colorado State Rams in a non-conference battle. It is the second meeting all-time between the programs, with Michigan winning the first matchup in 1994. Michigan is coming off a 12-2 season and a Big Ten title, while Colorado State aims to bounce back from a 3-9 performance in 2021. The Wolverines will start Cade McNamara at quarterback in this opener as he continues to battle with J.J. McCarthy for the full-time starting role. 

Kickoff is at noon ET. Caesars Sportsbook lists the Wolverines as 30.5-point favorites at home, while the over/under, or total number of points Vegas thinks will be scored, is 61.5 in the latest Michigan vs. Colorado State odds. Before making any Colorado State vs. Michigan picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado State vs. Michigan and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Michigan vs. Colorado State:

• Michigan vs. Colorado State spread: Michigan -30.5 
• Michigan vs. Colorado State over/under: 61.5 points 
• Michigan vs. Colorado State money line: Michigan -15000, CSU +2200 
• CSU: The Rams ranked near the top of FBS with 39 sacks in 2021 
• MICH: The Wolverines are coming off a Big Ten title and a 12-win season 
• Michigan vs. Colorado State picks: See picks here.