The anticipation for a new season finally will end when the reigning Super Bowl champion Los Angeles Rams host the Buffalo Bills on Thursday in the 2022 NFL Kickoff Game. Los Angeles concluded a wildly entertaining 2021 postseason by defeating Cincinnati in Super Bowl LVI for the second championship in franchise history. The Rams routed Arizona 34-11 in the wild-card round before posting three-point victories against Tampa Bay, San Francisco and the Bengals en route to the title. Buffalo participated in the most exciting contest of those playoffs, a 42-36 overtime loss at Kansas City in which four leads were lost and 25 points were scored over the final two minutes of the fourth quarter.
Kickoff from SoFi Stadium is set for 8:20 p.m. ET. Buffalo is a 2.5-point favorite in the latest Bills vs. Rams odds from Caesars Sportsbook, while the over/under for total points scored is 53. Before making any Rams vs. Bills picks, make sure to check out the expert NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated Bills vs. Rams in the NFL Kickoff Game 2022 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Rams vs. Bills:
- Bills vs. Rams spread: Buffalo -2.5
- Bills vs. Rams over/under: 53 points
- Bills vs. Rams money line: Buffalo -135, Los Angeles +115
- BUF: Bills scored at least 31 points in 11 of their 19 games last season, including playoffs
- LAR: Rams have lost their last three home games against Buffalo
- Bills vs. Rams picks: See picks at SportsLine
Featured Game | Los Angeles Rams vs. Buffalo Bills
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