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Saints vs. Panthers prediction, odds, line, spread: 2022 NFL picks, Week 3 best bets from proven model

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The Week 3 NFL schedule features a NFC South rivalry game with the Carolina Panthers (0-2) and the New Orleans Saints (1-1) facing off at 1 p.m. ET on Sunday at Bank of America Stadium in Charlotte. The Panthers are in search of their first win in 2022 after losing their first two games of the season to the Cleveland Browns and New York Giants by a combined 5 points. The Saints are looking to rebound from a hard-fought 20-10 loss to Tom Brady and the Buccaneers last Sunday. All-Pro running back Alvin Kamara (ribs) remains questionable and will likely be a game-time decision for New Orleans.

New Orleans is favored by 2.5 points in the latest Panthers vs. Saints odds from Caesars Sportsbook, and the over/under is set at 41. Before making any Saints vs. Panthers picks, you need to see the NFL predictions and betting advice from the simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Panthers vs. Saints and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL betting lines for Panthers vs. Saints:

  • Panthers vs. Saints spread: Saints -2.5
  • Panthers vs. Saints over/under: 41 points
  • Panthers vs. Saints picks: See picks here

Featured Game | Carolina Panthers vs. New Orleans Saints

What you need to know the about Saints

The Saints defense, while talented, has been inconsistent thus far in 2022. They have defended the pass well, but are giving up an average of 136.5 yards on the ground per game, which could spell trouble against a Carolina team that relies heavily on

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