Several Super Bowl contenders will have a chance to make a statement as the Week 4 NFL schedule unfolds. The Buccaneers and Chiefs are coming off their first losses of the season, and now Patrick Mahomes and Tom Brady will try to avoid consecutive defeats when they square off on Sunday Night Football. The Week 4 NFL odds from Caesars Sportsbook list the Chiefs as one-point favorites. After suffering a 31-10 setback in their opener, the Rams have reeled off two straight wins, but the defending champs are 1.5-point underdogs on the road against the 49ers on Monday in the latest NFL spreads.
Other notable Week 4 NFL Vegas odds include Bills (-3.5) vs. Ravens, Titans vs. Colts (-3) and Jaguars vs. Eagles (-6.5). Which spreads, totals and money lines should you target in your Week 4 NFL bets? All of the Week 4 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 4 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 4 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 4 NFL predictions
One of the model’s strongest Week 4 NFL picks is that the Steelers (-3) cover against the Jets. Joe Flacco’s intriguing start to the season appeared to come to an end in Week 3, when he completed just 28-of-52 passes with no touchdowns and two interceptions in a loss to Cincinnati. Meanwhile, quarterback Zach Wilson will make his return to action in Week 4 following his recovery from a preseason meniscus injury.
While Wilson’s return is bad news for Flacco, it should be welcome to those backing the Steelers. Wilson wasn’t dangerous when he was on the field last season and should be even less so this week if he is cleared to play. The model predicts that Wilson will just clear 200 yards passing with a turnover against a diminished Pittsburgh…
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