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Cardinals vs. Seahawks odds, line, spread: 2022 NFL picks, Week 6 predictions from proven computer model

Cardinals vs. Seahawks odds, line, spread: 2022 NFL picks, Week 6 predictions from proven computer model


An NFC West clash is set for Sunday as Geno Smith, D.K. Metcalf and the Seattle Seahawks (2-3) host Kyler Murray and the Arizona Cardinals (2-3). Arizona lost in its bid to hand the Eagles their first loss of the season in Week 5, falling 20-17. Meanwhile, the Seahawks engaged in a shootout with the Saints but came up on the losing end, 39-32. The all-time series is virtually even through 46 games, with Seattle having 23 wins, Arizona having 22 victories, and there being one tie.

Kickoff from Lumen Field is set for 4:05 p.m. ET. Arizona is favored by 2.5 points in the latest Seahawks vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 50.5. Before entering any Cardinals vs. Seahawks picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Seahawks vs. Cardinals. You can head to SportsLine to see its picks. Here are several NFL betting lines for Cardinals vs. Seahawks:

  • Seahawks vs. Cardinals spread: Cardinals -2.5
  • Seahawks vs. Cardinals over/under: 50.5 points
  • Seahawks vs. Cardinals picks: See picks here

What you need to know about the Seahawks

The Seahawks came within a touchdown against the New Orleans Saints this past Sunday, but they wound up with a 39-32 loss. Seattle’s loss shouldn’t obscure the performances of QB Geno Smith, who passed for three TDs and 268 yards, and WR Tyler Lockett, who caught five passes for two TDs and 104 yards. Near the top of the highlight reel was Smith’s 50-yard TD bomb to WR DK Metcalf in the first quarter.

Seattle leads the NFL with 5.5 yards per carry but the team lost starting RB Rashaad Penny (leg) for the season versus the Saints. That thrusts second-round rookie Kenneth Walker III into the starting lineup and he impressed last week, rushing for 88 yards and a touchdown on just eight carries. But as good as Seattle has been on the ground, it has been equally as bad defending the run as the…

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