The Los Angeles Chargers will play their first game in the post-Brandon Staley era when they host the Buffalo Bills in a Week 16 game on Saturday at SoFi Stadium. After spending months on the hot seat, Staley was fired last week, one day after the Chargers (5-9) were blown out, 63-21, by the Raiders. Staley went 24-24 in almost four full seasons in Los Angeles. Giff Smith, who previously served as outside linebackers coach, was named interim head coach. Smith and the Chargers will meet an 8-6 Bills team that is playing its best ball of the season.
Kickoff is scheduled for 8 p.m. ET. Buffalo is a 12-point favorite in the latest Bills vs. Chargers odds while the over/under for total points scored is 44.5. Before you make any Chargers vs. Bills picks or NFL predictions, you need to see the NFL betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has zeroed in on Bills vs. Chargers and identified its picks and predictions. You can see the model’s picks only at SportsLine. Here are several NFL odds and betting lines for Chargers vs. Bills:
- Bills vs. Chargers spread: Buffalo -12
- Bills vs. Chargers over/under: 44.5 points
- Bills vs. Chargers money line: Buffalo -772, Los Angeles +529
- BUF: James Cook ranks second in the league in rushing yards (968)
- LAC: Khalil Mack is tied for second in forced fumbles (five)
- Bills vs. Chargers: See picks here
Why the Bills can cover
Buffalo quarterback Josh Allen is one of the best dual-threat quarterbacks in the league. The 6-foot-5 Allen has had 10 games this season with a passing and rushing touchdown. That’s the most such games by any player in a season in NFL history. Allen also leads the league this season in touchdowns accounted for (37).
Allen and the rest of the Bills offense face a Los Angeles defense that has struggled mightily this season. The…
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