College Football

Illinois vs. Wyoming odds, line: 2022 college football picks, Week 0 predictions from model on 43-31 run

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The Illinois Fighting Illini host the Wyoming Cowboys in a non-conference matchup on Saturday afternoon. Both teams are eager to kick off their 2022 campaigns in a style with a victory. Illinois’ faithful will be in attendance hoping to give their guys a nice home-field advantage. They logged a 3-4 home record in 2021. Meanwhile, Wyoming had a 3-3 road record.

Kickoff from the Memorial Stadium in Champaign, Ill., is set for 4 p.m. ET. Caesars Sportsbook lists the Fighting Illini as 14-point favorites, up 4.5 points from the opening line in the latest Wyoming vs. Illinois odds. The over/under for total points is set at 43. Before locking in any Illinois vs. Wyoming picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Over the past six years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also finished the 2021-22 college football season on a 43-31 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Illinois vs. Wyoming and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for Wyoming vs. Illinois: 

  • Illinois vs. Wyoming spread: Fighting Illini -14
  • Illinois vs. Wyoming over/under: 43 points
  • Illinois vs. Wyoming money line: Fighting Illini -650, Cowboys +460
  • WYO: Over is 5-1 in Cowboys’ last six games overall
  • ILL: Fighting Illini are 4-1 ATS in their last five games overall
  • Illinois vs. Wyoming picks: See picks at SportsLine

Featured Game | Illinois Fighting Illini vs. Wyoming Cowboys

Why Wyoming can cover

Sophomore linebacker Easton Gibbs will be a physical anchor in the middle of this defensive unit. Gibbs is a quick and strong force with terrific reaction time. The California native formed an outstanding duo with 2022 third-round pick…

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