Florida State vs. Louisville odds, prediction: 2022 Week 3 college football picks from model on 50-41 run

The Florida State Seminoles look to start 3-0 for the first time since 2015 when they visit the Louisville Cardinals for an ACC college football showdown on Friday night. FSU last played Sept. 4, when it blocked an extra point with no time left to come away with a 24-23 victory against LSU in New Orleans. The Cardinals (1-1) opened their season with an ugly 31-7 loss to Syracuse but bounced back with a 20-14 road win against UCF last Friday. Now, Louisville will play its first game of the season at Papa John’s Cardinal Stadium, and it will be looking for a confidence-building victory. It’s a matchup of electrifying dual-threat quarterbacks, with Malik Cunningham leading the Cardinals and Jordan Travis calling the shots for FSU. The Seminoles are 17-6 all-time against Louisville, but the Cardinals have won four of the past six, including a 31-23 victory in Tallahassee last September.

Kickoff is set for 7:30 p.m. ET in Louisville, Ky. Caesars Sportsbook lists the Seminoles as the 2.5-point favorites in its latest Florida State vs. Louisville odds, and the over/under for total points is set at 56. Before making any Louisville vs. Florida State picks, be sure to check out the college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on FSU vs. Louisville and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Now, here are several college football odds and trends for Louisville vs. FSU:

• Florida State vs. Louisville spread: Seminoles -2.5
• Florida State vs. Louisville over/under: 56 points
• Florida State vs. Louisville money line: Seminoles -135, Cardinals +115
• FSU: Is 2-6 ATS as a favorite since coach Mike Norvell’s 2020 hiring.
• LOU: Is 3-4 ATS as a home underdog under Scott Satterfield (since 2021)
• Florida State vs. Louisville picks: See picks at SportsLine