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49ers vs. Rams odds, line: 2022 NFL picks, Week 8 predictions from proven computer model

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The San Francisco 49ers will try to bounce back from their two-game losing streak and extend their regular season dominance against the Los Angeles Rams on Sunday afternoon. San Francisco has won seven consecutive regular season meetings between these teams, although the Rams picked up a win in the NFC championship game last season. Los Angeles snapped a two-game losing skid with a 24-10 win over Carolina in its last game. 

Kickoff is set for 4:25 p.m. ET. The latest Rams vs. 49ers odds from Caesars Sportsbook list this game as a picke’m, while the over/under is set at 42. Before entering any 49ers vs. Rams picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2022 NFL season on an incredible 148-107 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Rams vs. 49ers. You can head to SportsLine to see its picks. Here are several NFL betting lines for Niners vs. Rams:

  • Rams vs. 49ers spread: Pick’em
  • Rams vs. 49ers over/under: 42 points
  • Rams vs. 49ers money line: Rams -110, 49ers -110 
  • Rams vs. 49ers picks: See picks here

Featured Game | Los Angeles Rams vs. San Francisco 49ers

Why the Rams can cover

Los Angeles might not have had much success against San Francisco in the regular season in recent years, but it beat the 49ers in the NFC title game last season and is coming off its bye week. The Rams were able to get back on track prior to their bye week, beating Carolina by two touchdowns. They are facing a San Francisco defense that was exposed by Patrick Mahomes last week, allowing six touchdowns in seven drives. 

The 49ers also gave up 9.1 yards per play against Kansas City, which…

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