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Panthers vs. Lions odds, line, spread: 2022 NFL picks, Week 16 predictions from proven computer model

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The Detroit Lions will try to extend their three-game winning streak when they face the Carolina Panthers on Saturday afternoon. Detroit has jumped into Wild-Card contention after winning six of its last seven games. Carolina had its two-game winning streak snapped in a 24-16 loss to Pittsburgh last week, but the Panthers are only one game back of Tampa Bay in the NFC South standings. 

Kickoff is set for 1 p.m. ET. Detroit is favored by 2.5 points in the latest Panthers vs. Lions odds from Caesars Sportsbook, while the over/under is set at 43.5. Before entering any Lions vs. Panthers picks, you’ll want to see the NFL predictions from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Panthers vs. Lions. You can head to SportsLine to see its picks. Here are several NFL betting lines for Panthers vs. Lions:

  • Panthers vs. Lions spread: Panthers +2.5
  • Panthers vs. Lions over/under: 43.5 points
  • Panthers vs. Lions money line: Carolina +115, Detroit -135
  • Panthers vs. Lions picks: See picks here

Featured Game | Carolina Panthers vs. Detroit Lions

Why the Panthers can cover

Carolina might be coming off a loss to Pittsburgh, but it has been an underrated team during the second half of the season. The Panthers had won three of their previous four games, despite being underdogs in all three wins. They still have a realistic shot to make the playoffs as well, trailing Tampa Bay by just one game in the standings after having picked up a win against the Buccaneers earlier in the season. 

The Panthers are ranked inside the top 15 in the NFL…

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